Skin sensitization testing: Embracing the potential of in vitro methods for assessing fragrance chemicals

The study “Common fragrance chemicals activate dendritic cells in coculture with keratinocytes” published on 23 April 2023, by Niklas Peter and co-authors, aimed to assess the effectiveness of a 2D coculture model comprising keratinocytes and dendritic cells (DCs) in evaluating the skin sensitization potency of weak to moderately sensitizing fragrance chemicals. Additionally, the researchers aimed to investigate the behavior of fragrances and their oxidation products in the in vitro model and compare the findings to in vivo data, providing valuable insights into the potential of the coculture model for assessing skin sensitization potency.